Bright-NP (CAS 158563-45-2)

Bright-NP, CAS 158563-45-2: personal care ingredient from MCP Factory (MCPBiotechnology). INCI Name: Nonapeptide-1; Molecular Formula: C61H87N15O9S…

INCI Name: Nonapeptide-1
CAS: 158563-45-2
Molecular Formula: C61H87N15O9S
Nonapeptide-1 is an alpha-melanocyte-stimulating hormone (α-MSH) antagonist that can reduce melanin production and has a whitening effect.
Product Information:
Alpha-melanocyte-stimulating hormone (α-MSH) is a short peptide consisting of 13 amino acids. When α-MSH binds to its receptor (MC1R), it will activate the downstream melanin synthesis pathway, resulting in increased melanin production and skin darkening. Nonapeptide-1, a biomimetic peptide designed to mimic the sequence of α-MSH, competitively inhibits the binding of α-MSH to MC1R. By blocking the melanin synthesis pathway, Nonapeptide-1 can effectively reduce melanin production at its source, leading to skin whitening effects.
Reference: C. Li et al., Biomolecules, 2022, 12(12), 1874.
Efficacy: Experimental conditions: B16F0 cells; Blank control: complete medium; Test group: Nonapeptide-1+200 J/cm2 UVB
Results: Nonapeptide-1 can inhibit the generation of melanin in a concentration-dependent manner.
Experimental conditions: Human epidermal melanocytes; Blank control: Cell culture medium; Negative control: 15 J/cm2 UVA; Test group: 15 J/cm2 UVA+30 ppm nonapeptide-1
Results: Nonapeptide-1 can effectively inhibit the expression of Microphthalmia-associated transcription factor (MITF) and tyrosinase, resulting in a brightening and whitening effect.
Reference: J. Chen et al., Postepy Dermatol. Alergol., 2022, 39(2), 327, 335.
Safety: Nonapeptide-1 exhibits no cytotoxicity within the tested concentration range (0−1000 ppm). It has been extensively utilized in various skincare products, with no reported adverse reactions.
Formulation Guidelines:
– Recommended level of use: 50−500 ppm
– Nonapeptide-1 is highly soluble in water and is compatible with most of cosmetic active ingredients.
– Nonapeptide-1 has high biological activity, and should be processed below 45 °C and added at the final stage of formulation.

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